Incorporation of β-sitosterol into the membrane increases resistance to oxidative stress and lipid peroxidation via estrogen receptor-mediated PI3K/GSK3β signaling

► The antioxidant effect of BS in plasma membrane. ► Incorporation of BS into cell membrane prevented GOX-induced oxidative stress and lipid peroxidation. ► Membrane BS exerted antioxidant activity via ER-induced PI3K/GSK3β.