Electrochemistry of cytochrome c immobilized on cardiolipin-modified electrodes: A probe for protein-lipid interactions

► PC/CL supported films were used to study electrochemistry of immobilized cyt c. ► AC voltammetry experiments showed two subpopulations of immobilized cyt c. ► At high ionic strength, only hydrophobically bound cyt c is detected. ► Redox behavior of cyt c depends on the structure of the FA chains carried by CL.