Biochemical and pharmacological properties of a new thrombin-like serine protease (Russelobin) from the venom of Russell's Viper (Daboia russelii russelii) and assessment of its therapeutic potential

► First report of high mass thrombin-like serine protease from Russell's Viper venom ► Preferentially releases FPA from fibrinogen, producing hypofibrinogenemia ► Extensive post-translational glycosylation protecting against endogenous inhibitors ► Non-toxic to mice and shows in vitro and in vivo defibrinogenating activity ► High potential for use as a defibrinogenating drug and/or for drug design