Proteome analysis identified human neutrophil membrane tubulovesicular extensions (cytonemes, membrane tethers) as bactericide trafficking

► Human neutrophils develop 200 nm wide and very long extensions (cytonemes). ► Cytonemes consist of lined up membrane tubules and vesicles of the same diameter. ► Neutrophils establish contacts with cells and bacteria over distance via cytonemes. ► Proteome analysis and HPLC revealed secretory granular bactericides in cytonemes. ► Cytonemes are bactericide trafficking establishing direct contacts with destination.