PEP-1-metallothionein-III protein ameliorates the oxidative stress-induced neuronal cell death and brain ischemic insults

► The function of Metallothioneins (MT)-III protein in ischemia is still unclear. ► We construct a cell permeable PEP-1-MT-III fusion protein. ► Transduced PEP-1-MT-III protein highly protects against oxidative stress-induced cell death and ischemic insult in animal models. ► PEP-1-MT-III protein could be useful as a therapeutic agent for oxidative stress.