Collagen adhesin-nanoparticle interaction impairs adhesin's ligand binding mechanism

► The crystal structure of collagen‐binding region of RspB, rRspB31-348, was determined. ► rRspB31-348 binds to collagen by a unique mechanism called “Collagen Hug”. ► Bacterial adhesins were shown to be involved in biomaterial infection. ► Nanoparticle coated biomaterials showed reduced bacterial colonization on it. ► rRspB31-348-silver nanoparticle interaction impaired “Collagen Hug” mechanism.