Yeast 14-3-3 proteins participate in the regulation of cell cation homeostasis via interaction with Nha1 alkali-metal-cation/proton antiporter

► Yeast 14-3-3p participates in cation homeostasis and cationic-drug resistance. ► A genetic interaction was identified between yeast BMH1 and NHA1. ► A physical interaction between 14-3-3 proteins and Nha1 antiporter was shown. ► Interaction of 14-3-3p and Nha1 enhances the yeast survival upon salt stress.