Biocompatibility of mannan nanogel-safe interaction with plasma proteins

► Protein corona is quite specific comprising apolipoproteins B-100, A-I and E and HSA. ► Protein corona evolves over time, and the equilibrium is reached after hours to days. ► Mannan nanogel does not affect blood coagulation. ► Mannan nanogel retards the fibrillation of Aβ(M1-40) and β2m.