Thermostable direct hemolysin diminishes tyrosine phosphorylation of epidermal growth factor receptor through protein kinase C dependent mechanism

► TDH phosphorylates PKC-α in colon carcinoma cell line and causes its activation. ► Activated PKC-α downregulates tyrosine phosphorylation of EGFR. ► PKC-α exerts its effect on EGFR through MAPK activation.