Hereditary hemochromatosis and transferrin receptor 2

► Recent data concerning the regulation of iron homeostasis in the body by the liver is discussed. ► Transferrin receptor 2 plays a distinct role in the regulation of hepcidin. ► Transferrin receptor 2 is controlled both transcriptionally and posttranscriptionally at the level of protein stability. ► Transferrin receptor 2 also plays a role in erythropoiesis. ► The regulation of hepcidin transcription is controlled by both iron through Tf saturation and BMP6 and by inflammation.