Redox regulation in respiring Saccharomyces cerevisiae

► Intra-organelle redox shuttling rapidly re-routes the reaction network. ► Mitochondrial criticality is a causal effect in metabolic re-routing. ► Thiols rapidly respond to regulate metabolic re-routing. ► Complex redox transcription factor network shows non-linear behaviours. ► Yeast redox systems are non-linear leading to stable oscillatory dynamics.