Differences in the fractional abundances of carbohydrates of natural and recombinant human tissue factor

► Natural human placental TF exhibits enhanced activity relative to a recombinant form. ► Major differences in carbohydrates and extent of glycosylation between the two forms. ► Extent and glycosylation type may augment TF activity in various systems/tissues. ► New insights into the biological contribution of carbohydrates on TF activity.