Redox regulation of ERK1/2 activation induced by sphingosine 1-phosphate in fibroblasts: Involvement of NADPH oxidase and platelet-derived growth factor receptor

► S1P induces activation of ERK1/2 by H2O2 production. ► Involvement of tyrosine kinase of PDGFr on redox regulation of ERK1/2. ► Cross-talk by transactivation between receptors of S1P and PDGFr.