Structure-activity relationship of acridine derivatives to amyloid aggregation of lysozyme

► Acridine derivatives affect amyloid aggregation of lysozyme. ► Extent of amyloid inhibition and depolymerization depends on acridine structure. ► Planarity and tautomerism of 9-aminoacridine core enhance anti-amyloid activity. ► IC50 and DC50 for most effective planar acridines at low micromolar concentrations. ► Identification of acridines with high antiamyloid activity and low cytotoxicity.