Inhibition of Rac activity alleviates lipopolysaccharide-induced acute pulmonary injury in mice

► Both Rac1 and Rac2 but not CDC42 or RhoA are activated in LPS-challenged lung injury. ► Activation of Rac is important in lung injury, as evidenced by using Rac inhibitor. ► Inhibition of Rac attenuates injury through decreasing migration and permeability. ► Rac could be a potential target for therapeutic intervention of pulmonary inflammation.