The induction of human CL-P1 expression in hypoxia/reoxygenation culture condition and rat CL-P1 after ischemic/reperfusion treatment

► We investigated how hypoxic and oxidative stress induced CL-P1 and LOX-1 expression. ► Hypoxia/reoxygenation induced CL-P1 mRNA and protein expression in HUVECs. ► The rat carotid artery after treatment of ischemia increased the CL-P1 expression. ► CL-P1 up-regulation was induced in vitro and in vivo oxidative stress.