کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10801687 | 1055629 | 2016 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Targeting and insertion of peroxisomal membrane proteins: ER trafficking versus direct delivery to peroxisomes
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کلمات کلیدی
APXTMSSRPPTSRibosome nascent chain complexPBDRNCPMPsPeroxisomal biogenesis disorder - اختلال بیوژنز پراکسیومالtransmembrane segment - بخش غشاییTransmembrane segments - بخشهای غشاییtail-anchored - دم پایینیsignal recognition particle - ذرات شناخت سیگنالZellweger syndrome - سندروم ZellwegerTargeting signals - سیگنال هدفendoplasmic reticulum - شبکه آندوپلاسمی Protein trafficking - قاچاق پروتئینascorbate peroxidase - پراکسیداز آسکورباتیPeroxisomal membrane proteins - پروتئین های غشایی پروکسیومGET - گرفتن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The importance of peroxisomes is highlighted by severe inherited human disorders linked to impaired peroxisomal biogenesis. Besides the simple architecture of these ubiquitous and dynamic organelles, their biogenesis is surprisingly complex and involves specialized proteins, termed peroxins, which mediate targeting and insertion of peroxisomal membrane proteins (PMPs) into the peroxisomal bilayer, and the import of soluble proteins into the protein-dense matrix of the organelle. The long-standing paradigm that all peroxisomal proteins are imported directly into preexisting peroxisomes has been challenged by the detection of PMPs inside the endoplasmic reticulum (ER). New models propose that the ER originates peroxisomal biogenesis by mediating PMP trafficking to the peroxisomes via budding vesicles. However, the relative contribution of this ER-derived pathway to the total peroxisome population in vivo, and the detailed mechanisms of ER entry and exit of PMPs are controversially discussed. This review aims to summarize present knowledge about how PMPs are targeted to the ER, instead of being inserted directly into preexisting peroxisomes. Moreover, molecular mechanisms that facilitate bilayer insertion of PMPs among different species are discussed. This article is part of a Special Issue entitled: Peroxisomes edited by Ralf Erdmann.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1863, Issue 5, May 2016, Pages 870-880
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1863, Issue 5, May 2016, Pages 870-880
نویسندگان
Peter U. Mayerhofer,