The novel interaction between microspherule protein Msp58 and ubiquitin E3 ligase EDD regulates cell cycle progression

► Microspherule protein Msp58 forms a novel complex with E3 ubiquitin ligase EDD. ► Msp58 and EDD directly interact and co-localize in the nucleoplasm. ► Two regions of Msp58 are sufficient to bind EDD independently. ► EDD negatively regulates the protein level of Msp58. ► The Msp58/EDD complex regulates cyclin levels and cell cycle progression.