The FOX transcription factor Hcm1 regulates oxidative metabolism in response to early nutrient limitation in yeast. Role of Snf1 and Tor1/Sch9 kinases

► The Fox transcription factor Hcm1 translocates to the nucleus by nutrient limitation. ► Hcm1 transcriptional activity is activated when both glucose and nitrogen decrease. ► Snf1, the yeast AMPK, phosphorylates Hcm1 and increases its nuclear localization. ► Tor1/Sch9 pathway negatively regulates Hcm1, promoting its nuclear exclusion. ► Hcm1 allows cell adaptation to nutrient deficiency by enhancing oxidative metabolism.