1α,25-Dihydroxyvitamin D3 mechanism of action: Modulation of L-type calcium channels leading to calcium uptake and intermediate filament phosphorylation in cerebral cortex of young rats

► 1α,25-Dihydroxyvitamin D3 induces Ca2 + uptake and cytoskeleton phosphorylation. ► The mechanism of hormone action involves the participation of K+ and Cl− channels. ► Na+/K+ ATPase inhibition might lead to calcium uptake via L-VDCC. ► Protein kinases are involved in the L-VDCC opening and cytoskeleton phosphorylation. ► 1,25D-induced calcium entry might participate in modulation of neurotransmission.