Low electric fields induce ligand-independent activation of EGF receptor and ERK via electrochemical elevation of H+ and ROS concentrations

► Low electric field (LEF) is involved in biological processes affecting EGFR signaling. ► Ligand-independent EGFR activation with subsequent downstream signaling is induced following cell exposure to LEF. ► LEF exert its effects via electrochemical reactions, mostly pH decrease. ► Short exposure to LEF or low pH may significantly affect cell processes and lay down a basis for therapeutic treatments.