Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; Aβ; amyloid-β; BBB; blood-brain-barrier; CaMKII; calcium calmodulin kinase II; CFC; contextual fear conditioning test; DAG; diacylglycerol; F3; fibronectin type III module; FGFR; fibroblast growth factor receptor; GABAAR; γ-aminobutyric acid A recept
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Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; AM; adrenomedulin; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMY; amylin; AT; angiotensin type; β-CCT; beta-carboline-3-carboxylate-t-butyl ester; CT; calcitonin; CTR; calcitonin receptor; CLR; calcitonin receptor-like receptor; DZ; di
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; Phosphatidic acid; Diacylglycerol kinase; Phospholipase D; Membrane; Stress response; Hormonal regulation; ABA; abscisic acid; DGPP; diacylglycerol pyrophosphate; flg22; flagellin peptide; Gly3P; glycerol-3-phosphate; IAA; indol-3-acetic acid; LPP; lipid-
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; BCR; B-cell receptor; CTxB; cholera toxin B-subunit; GPMV; giant plasma membrane-derived vesicle; FCS; fluorescence correlation spectroscopy; FRET; Förster Resonance Energy Transfer; FP; fusion peptide; Ld; liquid disordered; Lo; liquid ordered; MRSA; me
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; AFM; atomic force microscopy; ANS; 1-anilino-8-naphthalene sulfonate; BLES; bovine lung extract surfactant; BAM; Brewster angle microscopy; BSA; bovine serum albumin; CLSE; calf lung surfactant extract; CMC; critical micellar concentration; DM-; dimyristo
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; Parkinson's disease; Striatum; Rotenone; Phospholipids; Dye-lipid complex; PD; Parkinson's disease; AD; Alzheimer's disease; DA; Dopaminergic neuron; SNpc; Substantia nigra pars compacta; ROT; Rotenone; DMSO; Dimethyl sulfoxide; PLs; Phospholipids; PC; Ph
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; 5HT3R; 5-hydroxytryptamine receptor, subtype 3; ATP; Adenosine triphosphate; BK; big potassium channels; Cho; cholesterol; CTD; C-terminal domain; ECD; extracellular domain; ELIC; Erwinia chrysanthemi ligand-gated ion channel; GABAAR; gamma-aminobutyric a
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; FAPP1; four-phosphate-adaptor protein 1; GFP; green fluorescent protein; OSBP; oxysterol-binding protein; OSH; oxysterol-binding protein homologs; P4M; PtdIns(4)P binding of SidM; PtdIns(4)P; phosphatidylinositol 4-phosphate; PtdIns(4,5)P2; phosphatidylin
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; Cytokinesis; Centralspindlin; Anillin; ESCRT complex; Abscission; ALIX; apoptosis-linked gene-2 interacting protein X; ANCHR; abscission/NoCut Checkpoint Regulator; CHMP; charged multivesicular body protein; CPC; chromosome passenger complex; ESCRT; Endos
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; Ach; acetylcholine (Ach); Ad; adrenaline; AKAP; A kinase anchoring protein; Ano1; anoctamin-1 Ca2 +-activated Clâ channel encoded by the ANO1 gene; α-SMA; α-smooth muscle actin; ASMCs; atypical smooth muscle cells; eYFP; enhanced-yellow fluorescent p
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; Septin; Protein-protein interaction; Protein-lipid interaction; GTP binding protein; CD; Circular dichroism; CSM; Center of spectral mass; DOPC; 1,2-Dioleoyl-sn-glycero-3-phosphocholine; GUV; Giant unilamelar vesicle; ITC; Isothermal titration calorimetry
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; Chol; cholesterol; BODIPY; boron dipyrromethene difluoride; CDC; cholesterol-dependent cytolysins; CHO; Chinese hamster ovary; CTL; cholestatrienol; DHE; dehydroergosterol; DOPC; 1,2-dioleoyl-sn-glycero-3-phosphocholine; DPPC; 1,2-dipalmitoyl-sn-glycero-3
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; Phosphatidylinositol 4,5-bisphosphate; Phospholipase C (PLC); G-protein coupled receptor (GPCR); Potassium channel; Calcium channel; Transient receptor potential channel (TRP channel);
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; AA; arachidonic acid; Aβ; fibrillar β-amyloid; ACC; acetyl-CoA carboxylase; Akt; protein kinase B; APP; amyloid precursor protein; ASAH2; neutral ceramidase; BA; benzyl alcohol; BBB; blood-brain-barrier; BMI; body mass index; BPM; bis(monoacylglycero)
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; CK; creatine kinase; DMD; Duchenne muscular dystrophy; EHD; Eps15 homology domain; FC; founder cell; FCM; fusion competent myoblasts; LGMD; limb girdle muscular dystrophy; PH; pleckstrin homology; PIP2; phosphatidylinositol 4,5-bisphosphate; PS; phosphati
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; AC; adenylyl cyclase; AKT; protein kinase B; AMPK; AMP-activated protein kinase; AnR; androgen receptor; ARF6; ADP ribosylation factor 6; CaMK; Ca2+-calmodulin dependent kinase; CaMKK; CaMK kinase; cAMP; cyclic adenosine 3â²,5â²-monophosphate; CDK5; cyc
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; BK; big potassium channel; BN-PAGE; blue native polyacrylamide gel electrophoresis; Cav; voltage-gated calcium; CNG; cyclic nucleotide-gated channels; CRAC; cholesterol binding sites; CTD; cytoplasmic domain; ENaC; epithelial sodium channels; FRET; Först
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; AP-AB; anti-phospholipid antibody(ies); APS; anti-phospholipid syndrome; BMP/LBPA; bis(monoacylglycero)phosphate/lysobisphosphatidic acid; CAD; cationic amphiphilic drug(s); Chol; cholesterol; CL; cardiolipin; ECV/MVB; endosomal carrier vesicle(s)/multive
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; DIC; differential interference contrast; HUVECs; human umbilical vein endothelial cells; PIP2; phosphatidylinositol 4,5-bisphosphate; TBS; Tris-buffered saline; DAG; 1,2-diacylglycerol; IP3; inositol 1,4,5-trisphosphate; MβCD; methyl-β-cyclodextrin; PI3
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; AC; adenylate cyclase; Ace; acetophenone; 2-APB; 2-aminoethoxydiphenyl borate; Ben; benzaldehyde; [Ca2+]i; intracellular calcium; CC; chelerythrine chloride; cH; cis-4-heptenal; CNG; cyclic nucleotide-gated; DAG; diacylglycerol; DMSO; dimethyl sulfoxide;
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; [Ca2+]i; intracellular concentrations of Ca2+; CalC; calphostin C; DAG; diacylglycerol; E2; estradiol; EOG; electro-olfactogram; ER; endoplasmic reticulum; F340/F380; ratio of fluorescence intensity excited at 340Â nm and 380Â nm; HBSS; HEPES buffered sta
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; PC; phosphatidylcholine; PE; phophatidylethanolamine; PS; phophatidylserine; PI; phosphatidylinositol; PG; phosphatidylglycerol; PA; phosphatidic acid; CL; cardiolipin; DPG; diphosphatidylglycerol; PIP2 or PI(4,5)P2; phosphatidylinositol 4,5-bisphosphate;
The beneficial effects of Zn on Akt-mediated insulin and cell survival signaling pathways in diabetes
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; Akt2-KO; Akt2 gene deletion; CHO; Chinese hamster ovary; DM; diabetes mellitus; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; GLUT4; glucose transporter type-4; GS; glycogen synthase; GSK-3; glycogen synt
Phospholipase C zeta and calcium oscillations at fertilisation: The evidence, applications, and further questions
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; Phospholipase C zeta (PLCzeta); Oocyte activation; Fertilisation; Sperm; Infertility; Assisted reproductive technology; PLCζ; phospholipase C-zeta; Ca2+; calcium; PIP20; phosphatidylinositol 4,5-bisphosphate; InsP3; inositol 1,4,5-trisphosphate; PI3P; ph
Calcium as a Trojan horse in mental diseases-The role of PMCA and PMCA-interacting proteins in bipolar disorder and schizophrenia
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; BD; bipolar disorder; CaM; calmodulin; CaN; calcineurin; ER; endoplasmic reticulum; GABA; γ-aminobutyric acid; GAP-43; growth associated protein 43; NCKX; Na+/Ca2+-K+ exchanger; NCX; Na+/Ca2+ exchanger; PIP2; phosphatidylinositol 4,5-bisphosphate; PMCA;
Phosphoinositide 3-kinase pathways and autophagy require phosphatidylinositol phosphate kinases
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; Phosphoinositide; Phosphatidylinositol phosphate kinase; Phosphatidylinositol 4,5-bisphosphate; Phosphoinositide 3-kinase; Autophagy; Signal transduction;
The role of insulin signalling in the endocrine stress response in Drosophila melanogaster: A mini-review
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; JH; juvenile hormone; JHE; JH-esterase; DA; dopamine; ALP; alkaline phosphatase; TH; tyrosine hydroxylase; OA; octopamine; TDC; tyrosine decarboxylase; 20E; 20-hydroxyecdysone; E20MO; ecdysone 20-monooxygenase; CA; corpus allatum; IIS; insulin/insulin-lik
The central serotonin2B receptor as a new pharmacological target for the treatment of dopamine-related neuropsychiatric disorders: Rationale and current status of research
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; 5-HT; serotonin; 5-HT2BR; 5-HT2B receptor; AC; adenylate cyclase; APDs; antipsychotic drugs; cAMP; cyclic adenosine monophosphate; CNS; central nervous system; DA; dopamine; DAG; diacylglycerol; DARPP-32; DA and c-AMP-regulated phosphoproteins Mr 32Â kDa;
Regulation of vascular tone homeostasis by NO and H2S: Implications in hypertension
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; ADRF; adipocyte-derived relaxing factor; AE; anion exchanger; ATP; adenosine triphosphate; BH4; tetrahydrobiopterin; BKCa; big conductance Ca2+-sensitive K+ channel; CaM; calmodulin; cAMP; cyclic adenosine monophosphate; CAT; cysteine aminotransferase; CB
Tools and drugs for uracil nucleotide-activated P2Y receptors
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; ADP; Adenosine 5â²-diphosphate; AP4A; P1,P4-Di(adenosine-5â²)-tetraphosphate; AR; Adenosine receptor; AR-C118925; 5-{[5-(2,8-Dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl)-3,4-dihydro-2-oxo-4-thioxo-1(2H)-pyrimidinyl]methyl}-N-(1H-tetrazol-5-yl)-2-furancarbo
Oncogenic mutations of PIK3CA and HRAS in carcinoma of cervix in South Indian women
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; Oncogenic mutations; Cervical cancer; Peripheral blood; PCR-CTPP method; PIK3CA; Phosphatidylinositol-4,5-Bisphosphate; 3-Kinase Catalytic Subunit Alpha; HRAS; Harvey rat sarcoma viral oncogene homolog; EGF; Epidermal Growth Factor; PDGF; Platelet Derived
Phospholipase C-dependent hydrolysis of phosphatidylinositol 4,5-bisphosphate underlies agmatine-induced suppression of N-type Ca2+ channel in rat celiac ganglion neurons
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; Agmatine; Imidazoline receptor; Cav2.2; Phosphatidylinositol 4,5-bisphosphate;
Metal ions and phosphatidylinositol 4,5-bisphosphate as interacting effectors of α-type plant phospholipase D
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; Brassica oleracea convar. capitata var. alba L.; Brassicaceae; Phospholipase D; C2 domain; Homology modelling; Molecular docking; Fluorescence; Activity; Calcium; PIP2; Mixed micelles; diac-PIP2; 1,2-diacetyl-glycero-3-phosphoinositol-4,5-bisphosphate; MD
Original articleSensory role of actin in auxin-dependent responses of tobacco BY-2
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; IAA; indole-3-acetic acid; 2,4-D; 2,4-dichlorophenoxyacetic acid; NAA; naphthalene acetic acid; GFP-FABD2; GFP-fimbrin actin-binding domain 2; MI; mitotic index; PA; phosphatidic acid; PIP2; phosphatidylinositol 4,5-bisphosphate; ADF2; actin-depolymerizat
Signaling Pathways Relevant to Nerve Growth Factor-induced Upregulation of Transient Receptor Potential M8 Expression
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; 4-OHT; 4-hydroxytamoxifen; ANOVA; analysis of variance; DAG; diacylglycerol; DMSO; dimethyl sulfoxide; DRG; dorsal root ganglion; EmGFP; Emerald green fluorescent protein; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; IP3; inositol 1,4,5-tris
Purinergic P2Y receptors: Molecular diversity and implications for treatment of cardiovascular diseases
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; ADP; adenosine 5â²-diphosphate; AgRP; agouti-related peptide; AMPK; 5â²-AMP-activated protein kinase; ApnA; diadenosine polyphosphate; ApoE; apolipoprotein E; AT1R; angiotensin II type 1 receptor; ATP; adenosine 5â²-triphosphate; BN-PAGE; blue native-p
ACAP3, the GTPase-activating protein specific to the small GTPase Arf6, regulates neuronal migration in the developing cerebral cortex
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; Small G protein; Arf6; Arf GAP; ACAP3; Neuronal migration; ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains; Arf; ADP-ribosylation factor; ARNO; Arf nucleotide binding site opener; BCIP; 5-bromo-4-chloro-3-indolyl phosphate; BRAG2; Brefeldin A
Stretch-induced actomyosin contraction in epithelial tubes: Mechanotransduction pathways for tubular homeostasis
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; ATP; adenosine triphosphate; DAG; diacylglycerol; ECM; extracellular matrix; FAK; focal adhesion kinase; GAP; GTPase activating protein; GDI; guanine dissociation factor; GEF; guanine nucleotide exchange factor; GPCR; G protein coupled receptor; HUVEC; Hu
Regulation of intracellular trafficking and secretion of adiponectin by myosin II
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; GLUT4; TGN; PIP2; ER-endoplasmic reticulum; GGA-golgi localizing gamma-adaptin ear homology ARF-binding proteins; GLUT4; glucose transporter 4; TGN; trans golgi network; PIP2; phosphatidylinositol 4,5-bisphosphate; PM; plasma membrane; HDM; high density m
Lipidomics in translational research and the clinical significance of lipid-based biomarkers
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; 5-HETE; 5-hydroxyicosatetraenoic acid; 12-HETE; 12-hydroxyicosatetraenoic acid; 15-HETE; 15-hydroxyicosatetraenoic acid; aa; diacyl; ae; acyl-alkyl; ACs; acylcarnitines; ACOG; The American College of Obstetricians and Gynecologists; AD; Alzheimer's dise
BRET-monitoring of the dynamic changes of inositol lipid pools in living cells reveals a PKC-dependent PtdIns4P increase upon EGF and M3 receptor activation
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; DAG; diacylglycerol; PPIns; phosphoinositides; RTK; receptor tyrosine kinase; GPCR; G-protein coupled receptor; Ins(1,4,5)P3; inositol 1,4,5-trisphosphate; PM; plasma membrane; BRET; bioluminescence resonance energy transfer; PLC; phospholipase C; PtdIns(
Membrane lipid compositional sensing by the inducible amphipathic helix of CCT
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; AI; auto-inhibitory; AH; amphipathic helix; CCT; CTP:phosphocholine cytidylyltransferase; CD; circular dichroism; CCTsol; soluble form of CCT; CCTmem; membrane-bound form of CCT; DAG; diacylglycerol; TAG; triacylglycerol; iPILA2; calcium-independent PLA2;
Characterization of the binding between a 70-kDa heat shock protein, HspA1A, and phosphoinositides
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; Heat-shock proteins; Lipid-binding; Liposomes; Membranes; Stress; Hsp70; seventy-kilodalton heat shock protein; NBD; nucleotide-binding domain; SBD; substrate-binding domain; PC; phosphatidylcholine; PI; phosphatidylinositol; PI(3)P; phosphatidylinositol
ER functions of oncogenes and tumor suppressors: Modulators of intracellular Ca2Â + signaling
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; a.a.; amino acid; ATP; adenosine triphosphate; BH domain; Bcl-2-homology domain; BI-1; Bax inhibitor-1; BIRD-2; Bcl-2/IP3R disruptor-2; BRCA1; breast and ovarian cancer susceptibility gene 1; [Ca2Â +]cyt; cytosolic Ca2Â + concentration; CLL; chronic lymph
Cool-temperature-mediated activation of phospholipase C-γ2 in the human hereditary disease PLAID
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; PLC; inositol-phospholipid-specific phospholipase C; SH2; Src homology domain 2; SH3; Src homology domain 3; PH; pleckstrin homology domain; spPH; split PH domain; PCI; phospholipase C inhibitor peptide; Rac; Ras-related C3 botulinum toxin substrate; BCR;
Inwardly rectifying Kir2.1 currents in human β-cells control electrical activity: Characterisation and mathematical modelling
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; Insulin secretion; Pancreatic beta-cells; Action potential firing; Electrical activity; Ion channels; Mathematical model; K(ATP); ATP-sensitive potassium (channels, current); AP; action potential; V; membrane potential; I-V; current/voltage (relationshi
Reversible chemical dimerizer-induced recovery of PIP2 levels moves clathrin to the plasma membrane
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; Endocytosis; Phosphoinositol 5-phosphatase; Clathrin; Adapter proteins; Phosphatidylinositol 4,5-bisphosphate;
Is hydrogen ion (H+) the real second messenger in calcium signalling?
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; PIP2; Phosphatidylinositol 4,5-bisphosphate; DAG; Diacylglicerol; IP3; Inositol 1,4,5-trisphosphate; PLC; Phospholipase C; cADPR; Cyclic ADP Ribose; NAADP; Nicotinic acid-Adenine dinucleotide phosphate; [Ca2Â +]c; cytosolic free Ca2Â + concentration; pH
Role of lipid microdomains in TLR-mediated signalling
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; ABCA1/G1; ATP-binding cassette, sub-family A/G, member 1; AP-1; activator protein 1; CARC; inverted “CRAC” domain; CD 14/36/55; cluster of differentiation 14/36/55; CRAC; cholesterol recognition amino-acid consensus sequence; CXCR4; C-X-C chemokine re
PI(4,5)P2-binding effector proteins for vesicle exocytosis
Keywords: فسفاتیدیلینوزیتول 4،5-بیسفسفات; PI; phosphosphatidylinositol; PI(4)P; phosphatidylinositol 4-monophosphate; PI(4,5)P2; phosphatidylinositol 4,5-bisphosphate; PLC; phospholipase C; PKC; protein kinase C; TIRF; total internal reflectance fluorescence; PALM; photoactivated localization mic