β-Estradiol-dependent activation of the JAK/STAT pathway requires p/CIP and CARM1

► p/CIP/CARM1 complex binds 204 proximal promoters in response to E2 in MCF-7 cells. ► Many p/CIP/CARM1 complex target genes have been implicated in cancer. ► 20% of target genes are transcriptionally altered following 12 h E2-stimulation ► Jak2 is a p/CIP/CARM1 complex target gene that is transcriptionally activated by E2 ► Chromatin modifications at Jak2 promoter support transcriptional permissiveness