Annexin A7 trafficking to alveolar type II cell surface: Possible roles for protein insertion into membranes and lamellar body secretion

► Suggested planar configuration can limit membrane insertion by annexin proteins. ► Stimulation of surfactant secretion increases annexin A7 on type II cell surface. ► Protein kinase activation increases cell surface annexin A7 possibly via lipid rafts. ► Recombinant annexin A7, however, failed to show insertion into artificial membranes. ► Phosphorylation could promote in vivo membrane penetration by annexin A7.