The Hsp90 chaperone machinery: Conformational dynamics and regulation by co-chaperones

► Hsp90 is a complex molecular chaperone machine. ► During the ATPase cycle Hsp90 undergoes large conformational changes. ► Hsp90 is subject to several posttranslational modifications that modify its function. ► Eukaryotic Hsp90 associates with a large cohort of co-chaperones. ► Co-chaperones drive Hsp90-client protein interactions.