The HSP90 complex of plants

► HSP90 is a highly conserved molecular chaperone involved in maturation and activation of signaling proteins in eukaryotes. ► In plants and animals, immune sensing NLR proteins are client proteins of HSP90. ► In the process of chaperoning NLR proteins, co-chaperons, RAR1 and SGT1 function together with HSP90. ► The structure and function of HSP90-SGT1-RAR1 complex are reviewed.