Heat shock protein 90 from neglected protozoan parasites

► Hsp90 is critically important for the growth of protozoan parasites in their hosts. ► Hsp90 of protozoan parasites senses and responds to environmental cues available in their hosts. ► Inhibition of Hsp90 abrogates growth of protozoan parasites in their hosts. ► Hsp90 from Giardia lamblia is organized as a split gene that undergoes ­trans-splicing.