The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2

► Syk binds tensin2 in a yeast two-hybrid assay. ► Syk binds the C-terminal SH2 and PTB domains of tensin2. ► Syk does not bind tensin1. ► Syk localizes in cells with tensin2 in cytoplasmic structures. ► Syk clustered by binding tensin2 is activated.