Human ether-Ã -go-go gene potassium channels are regulated by EGFR tyrosine kinase

► The EGFR kinase inhibitor AG556 suppresses hEAG1 current. ► Tyrosine phosphorylation of the channel protein is also inhibited by AG556. ► These inhibitory effects are countered by the PTP inhibitor orthovanadate. ► Tyr90, Try344 and Try485 are responsible for the tyrosine phosphorylation.