Angiopoietin-1 but not angiopoietin-2 promotes neutrophil viability: Role of interleukin-8 and platelet-activating factor

► First report of Ang1 pro-survival activity on neutrophils. ► Ang2 has no effect on neutrophil viability, apoptosis and necrosis. ► Combination of Ang1 with IL-8 or PAF has an additive effect on neutrophil viability. ► Ang1 pro-survival activity is Tie-2-dependent. ► Ang1-induced neutrophil viability is IL-8-dependent and PAF-independent.