Two free radical pathways mediate chemical hypoxia-induced glutamate release in synaptosomes from the prefrontal cortex

► H2O2-NMDA pathway mediated one part of the NaCN-induced glutamate release. ► Lipid peroxyl radicals-ATP synthase pathway mediated another part of the NaCN-induced glutamate release. ► Scavenging H2O2 and enhancing ATP synthase activity could completely abolish the NaCN-induced glutamate release.