Palmitoylation of TNF alpha is involved in the regulation of TNF receptor 1 signalling

► Palmitoylation of transmembrane TNF promotes its lipid raft integration. ► Palmitoylation of TNF is required for the processing of its intracellular fragments. ► Palmitoylation of TNF modulates the binding of soluble TNF to TNFR1. ► Palmitoylation of transmembrane TNF alters its interaction with TNFR1. ► Palmitoylation of transmembrane TNF modulates cellular responses to soluble TNF.