UCP2 inhibition triggers ROS-dependent nuclear translocation of GAPDH and autophagic cell death in pancreatic adenocarcinoma cells

► UCP2 inhibition stimulates ROS-dependent nuclear translocation of GAPDH. ► UCP2 inhibition induces ROS-dependent autophagy. ► Autophagy induced by UCP2 inhibition has an antiproliferative role. ► Genipin enhances autophagy induced by chemotherapy.