Comparative role of acetylation along c-SRC/ETS1 signaling pathway in bone metastatic and invasive mammary cell phenotypes

► c-Src-dependent activation of Ets1 was regulated by HDACs in bone-metastatic 1883 cells. ► c-Src/Ets1 pathway transactivated CXCR4 and caused nuclear-tyrosine phosphorylation only in 1833 clone. ► CXCR4-molecular changes due to c-Src had a functional role for metastasis chemoinvasion. ► c-Src expression, as occurs in response to microenvironmental stimuli, might influence migratory dissemination and gene expression profile. ► c-Src may be a predictive biomarker to define metastasis sensitivity patterns to HDAC inhibitors.