Lactoferrin inhibits neutrophil apoptosis via blockade of proximal apoptotic signaling events

► The anti-apoptotic effect of lactoferrin on neutrophils is dependent on its iron saturation status. ► The anti-apoptotic effect of lactoferrin is mediated at an early stage in neutrophil apoptosis. ► Lactoferrin inhibits generation of ceramide and activation of caspase 8 and Bax, as well as Bid cleavage and loss of Mcl-1.