Cell metabolism: An essential link between cell growth and apoptosis

►Growth stimuli and nutrient availability must be matched to avoid apoptotic stress. ►Oncogenic kinases can drive metabolism in growth factor deficiency. ►Bcl-2 family proteins respond to nutrient limitation to promote apoptosis. ►P53 plays a major role to mediate nutrient stress and induce Puma expression. ►Puma and Noxa promote while Mcl-1 suppresses apoptosis in nutrient deficiency.