کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10802789 1055714 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A chimeric receptor of the insulin-like growth factor receptor type 1 (IGFR1) and a single chain antibody specific to myelin oligodendrocyte glycoprotein activates the IGF1R signalling cascade in CG4 oligodendrocyte progenitors
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
A chimeric receptor of the insulin-like growth factor receptor type 1 (IGFR1) and a single chain antibody specific to myelin oligodendrocyte glycoprotein activates the IGF1R signalling cascade in CG4 oligodendrocyte progenitors
چکیده انگلیسی
► The aim is to produce neural progenitor cells capable of insulin-like-growth-factor (IGF)-independent growth. ► This study characterises a chimeric receptor (ChR) with the IGF receptor type 1 signalling domain. ► The ectodomain of the ChR is a single chain antibody to myelin oligodendrocyte glycoprotein (MOG), a brain-specific ligand. ► ChR activation is shown by increased phosphotyrosine content and dimerization in response to MOG. ► CG4 oligodendrocyte progenitors transduced with the ChR and expressing endogenous MOG grow independently of insulin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1813, Issue 8, August 2011, Pages 1428-1437
نویسندگان
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