Regulation of IGF-1-dependent cyclin D1 and E expression by hEag1 channels in MCF-7 cells: The critical role of hEag1 channels in G1 phase progression

►IGF-1 regulates cyclin D1 and E expression in breast cancer. ►hEag1 is involved in the G1 phase progression in MCF-7 breast cancer cell line. ►hEag1 is a key actor of the IGF-1 pathway which modulates cyclin D1 and E expression. ►hEag1 activity occurs in G1 phase prior to the up-regulation of cyclins D1 and E.