Darier disease : A disease model of impaired calcium homeostasis in the skin

► Mutations in ATP2A2 encoding the sarco/endoplasmic reticulum Ca2+-ATPase isoform 2 (SERCA2). ► Loss of Ca2+ transport from the cytosol to the lumen of the ER. ► Depleted ER Ca2+ stores ► Loss of cell-to-cell adhesion and abnormal keratinisation.