Lipids ‒ A key for hepatitis C virus entry and a potential target for antiviral strategies

► We focus on the entry of the hepatitis C virus (HCV) into human hepatocytes. ► We examine HCV membrane lipid composition and its relationship to viral structure. ► We examine the role played by lipids of viral and cellular membranes on HCV entry. ► We address the question of lipids as potential targets for anti-HCV therapies.