Regulation of gene expression and the transcription factor cycle hypothesis

► Exposure of the “Genon” concept extending the operon model to eukaryotic systems. ► Review of gene expression in eukaryotes in view of recent data confirming transcription of most of the genome. ► RNA processing and stepwise control of expression within the “Cascade Regulation” scheme. ► The “Transcription Factor Cycle” hypothesis suggesting transfer of factors from DNA to RNA.