DNA hypomethylation and oxidative stress-mediated increase in genomic instability in equine sarcoid-derived fibroblasts

► The proliferative potential of sarcoid-derived fibroblasts is increased in vitro. ► BPV-1-infected cells are genomically instable. ► Sarcoid-derived fibroblasts suffer from oxidative stress. ► Global DNA methylation status is decreased in sarcoid-derived fibroblasts. ► Altered DNA methylation and redox status contribute to genomic instability in BPV-1-infected cells.