Protective effect of esculetin on hyperglycemia-mediated oxidative damage in the hepatic and renal tissues of experimental diabetic rats

► Oxidative stress plays an important role in the etiology of diabetes. ► Coumarins are health benefits derived from consuming fruits and vegetables. ► Esculetin is a coumarin derivative found in Matricaria chamomilla L., Plant. ► This plant used as a herbal tea or supplementary food all over the world. ► Esculetin at 40 mg/kg BW possess antioxidant activity in STZ rats.