Isolation, enzymatic characterization and antiedematogenic activity of the first reported rattlesnake hyaluronidase from Crotalus durissus terrificus venom

► CdtHya1 is the first hyaluronidase isolated from rattlesnake venoms. ► Functional and structural characterization of CdtHya1. ► CdtHya1 presents high antiedematogenic activity. ► CdtHya1 increased the diffusion of crotoxin and phospholipase A2 through mice tissues. ► CdtHya1 potentiated crotoxin action, which was evidenced by mice death.