Lipids, curvature stress, and the action of lipid prodrugs: Free fatty acids and lysolipid enhancement of drug transport across liposomal membranes

► We describe how molecular shape modify liposomal permeability barrier. ► Free fatty acids and lysolipids are found to enhance release of doxorubicin from liposomes. ► Drug-release is found to depend on the phase state of the liposome.