Self assembly of human septin 2 into amyloid filaments

► Self Assembly of Human Septin 2 into Amyloid Filaments. ► SEPT2 presents regions with high probability of aggregation and/or amyloid formation. ► At higher temperatures, SEPT2 and SEPT2G presented a transition to β-sheet structure. ► ThT binds to SEPT2 and SEPT2G. ► Amyloid like filaments were visualized by Electron microscopy.