The C-terminal polyproline-containing region of ELMO contributes to an increase in the life-time of the ELMO-DOCK complex

► NMR and SPR analyses of the interaction between ELMO and the SH3 domain of DOCK. ► The DOCK SH3 interacts with ELMO, regardless of the presence of the C-terminal end. ► The ELMO C-terminal end enhances the half-life of the DOCK-ELMO complex.