The mechanism of antioxidant activity of IRFI005 as a synthetic hydrophilic analogue of vitamin E

► The results clearly showed that IRFI005 enters the cells and suppresses oxidative compounds. ► Two radical molecules were scavenged by the one IRFI005 molecule. ► IRFI005 showed higher antioxidant and radical-scavenging potency at physiological pH. ► IRFI005 was not toxic to the L6-myoblast cells.