Effect of sodium tetrathionate on amyloid fibril: Insight into the role of disulfide bond in amyloid progression

► Sodium tetrathionate shows inhibitory effect toward amyloidogenesis. ► Sodium tetrathionate can also dissolve pre-formed amyloid. ► Formation of correct disulfide bond appears to have key role in amyloid progression. ► Role of hydrophobic clusters in amyloid progression is not clear.