کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10804489 | 1057276 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bacterial efflux systems and efflux pumps inhibitors
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کلمات کلیدی
EPIPAβNTMSRNDP-gpMFSABCSMRSDRMDRSARP-glycoprotein - P-گلیکوپروتئینmethicillin-resistant S. aureus - S. aureus مقاوم به متیسیلینMRSA - استافیلوکوک اورئوس مقاوم به متی سیلین یا MRSA transmembrane segment - بخش غشاییMajor facilitator superfamily - بزرگترین تسهیل کننده خانوادگیMate - رفیقStructure–activity relationships - روابط ساختاری-فعالیتEfflux systems - سیستم های خروجیBacterial resistance - مقاومت باکتریاییMulti-drug resistance - مقاومت چند داروییEfflux pump inhibitors - مهار کننده های پمپ EffluxEfflux pump inhibitor - مهار کننده پمپ EffluxATP-binding cassette - کیت اتصال به ATP
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
It is now well established that bacterial resistance to antibiotics has become a serious problem of public health that concerns almost all antibacterial agents and that manifests in all fields of their application. Among the three main mechanisms involved in bacterial resistance (target modification, antibiotic inactivation or default of its accumulation within the cell), efflux pumps, responsible for the extrusion of the antibiotic outside the cell, have recently received a particular attention. Actually, these systems, classified into five families, can confer resistance to a specific class of antibiotics or to a large number of drugs, thus conferring a multi-drug resistance (MDR) phenotype to bacteria. To face this issue, it is urgent to find new molecules active against resistant bacteria. Among the strategies employed, the search for inhibitors of resistance mechanisms seems to be attractive because such molecules could restore antibiotic activity. In the case of efflux systems, efflux pump inhibitors (EPIs) are expected to block the pumps and such EPIs, if active against MDR pumps, would be of great interest. This review will focus on the families of bacterial efflux systems conferring drug resistance, and on the EPIs that have been identified to restore antibiotic activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimie - Volume 87, Issue 12, December 2005, Pages 1137-1147
Journal: Biochimie - Volume 87, Issue 12, December 2005, Pages 1137-1147
نویسندگان
Béatrice Marquez,